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KMID : 1011920230240010009
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International Journal of Arrhythmia
2023 Volume.24 No. 1 p.9 ~ p.9
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Historical perspective and recent progress in cardiac ion channelopathies research and clinical practice in Hong Kong
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Keith Sai Kit Leung
Helen Huang
Cheuk To Chung
Danny Radford
Ishan Lakhani
Christien Ka Hou Li
Tommy Wai Kei Li
Simon Ranjithkumar
Rajesh Rajan
Leonardo Roever
Sebastian Garcia-Zamora
George Bazoukis
Tong Liu
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Abstract
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Cardiac ion channelopathies encompass a set of inherited or acquired conditions that are due to dysfunction in ion channels or their associated proteins, typically in the presence of structurally normal hearts. They are associated with the development of ventricular arrhythmias and sudden cardiac death. The aim of this review is to provide a historical perspective and recent advances in the research of the cardiac ion channelopathies, Brugada syndrome, long QT syndrome and catecholaminergic polymorphic ventricular tachycardia, in Hong Kong, China. In particular, recent works on the development of novel predictive models incorporating machine learning techniques to improve risk stratification are outlined. The availability of linked records of affected patients with good longitudinal data in the public sector, together with multidisciplinary collaborations, implies that ion channelopathy research efforts have advanced significantly.
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KEYWORD
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Ion channelopathies, Brugada syndrome, Catecholaminergic polymorphic ventricular tachycardia, Long QT syndrome, Sudden cardiac death, Risk stratifcation, Machine learning
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